Couple droplet drying kinetics to CFD simulation of spray dryer

Job description
Couple droplet drying kinetics to CFD simulation of spray dryer
Spray drying, Computational fluid dynamics, transport phenomena

Are you currently pursuing a master’s degree with a burning interest in pharmaceutical development and computation fluid dynamics? Then this master’s thesis project at AstraZeneca might be of interest to you!

The thesis is aimed for: Master's students
Program area:   Chemistry/modelling
Student Location: AstraZeneca Gothenburg, Sweden
Start: January 2022 to June 2022, or as agreed with the student

A focus for AstraZeneca Gothenburg is to develop inhaled drugs for the treatment of respiratory diseases such as asthma. A critical domain in this work is to produce active pharmaceutical ingredients (API) particles with appropriate properties e.g. size and morphology, where spray drying is one of efficient formulation platforms. To this end, enabling the quantitative prediction of spray drying process will provide us an efficient tool to optimize and accelerate the development process.

Responsibilities
This project aims to coupling drying kinetics to CFD simulation to enable the predict of particle properties e.g. morphology for various spray dryers across scales.

Responsibilities include building and improving CFD simulations on OpenFOAM based on existing CFD works on ANSYS Fluent. Coupling droplet drying kinetics models based on heat and mass transfer to CFD simulation to resolve particle formation at individual particle level will be a critical part of the work.

Validating the simulations with available experimental data will also be included.

The work is to be conducted from January to June 2022, or as agreed with the student.

Qualifications
Essential Requirements
Experience computational fluid dynamics
Solid understanding in transport phenomena and mathematical modelling
Experience in computer programming e.g. C++, python
Pursuing a master’s degree in a relevant engineering discipline
Excellent problem solving skills  

Desirable Requirements
Experience in working in the labs


Application
 Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.

Deadline for application: 2021-12-15

For more information: Veronika Knudsen veronika.knudsen@randstad.se or Kerstin Karlsson kerstin.karlsson@randstad.se 

About the company
 AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.