Thesis work: 30 credit Master's thesis project at AstraZeneca

Job description
Application of amorphous classification system and glass forming ability in pre-formulation design of small organic molecules

Do you want to study about the importance of solid state in preformulation of drug candidate molecules in the company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!

Program area: Chemistry and Physics
Student Location: AstraZeneca Gothenburg, Sweden
Start: Autumn 2021 (flexible start)
Supervisor: Dr. Okky Putra and Dr. Phil Corner (Solid state senior scientists, Early Product Development and Manufacture, Pharmaceutical Sciences) and  Prof. Lars Öhstrom (Department of Chemistry and Chemical Engineering, Chalmers Tekniska Högskola)

Opportunity
We have an exciting opportunity for a Master’s student to determine amorphous classification system and glass forming ability of small organic molecules in relation to their developability in pre-formulation research. This opportunity can be expanded to include building a database and applying it to simulation and machine learning that is used for pre-formulation research.


Background
Determination of amorphous classification system and glass forming ability of small organic molecules: Amorphous classification system and glass forming ability are important parameters in pre-formulation of the drug molecules and also in informing alternative solid forms for development, i.e. co-amorphous systems. However, there is no systematic database for these parameters. The aim of this research project is to determine the value of these parameters accurately in a systematic manner for small organic molecules that are typically used in pharmaceutical development. This database can be further used for machine learning and simulation in pre-formulation research.



Responsibilities
Task and methodology
Thermal analysis including DSC (Differential Scanning Calorimetry) and TGA (Thermo Gravimetric Analysis) measurements
Database building


Qualifications
Basic understanding of solid state chemistry and its related techniques


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.

Deadline for application: 2021-09-12

For more information: Kerstin Karlsson kerstin.karlsson@randstad.se or Veronika Knudsen veronika.knudsen@randstad.se.



About the company
At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of  coffee or a stroll on our “walk and talk” meeting trail. AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.