Associate Principal Scientist In Vitro Cardiovascular Biology

Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future - here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide.

We are now recruiting an Associate Principal Scientist with deep knowledge in cardiovascular disease to join the Bioscience Cardiovascular in vitro team within the Early Cardiovascular, Renal and Metabolism (ECVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular-, chronic kidney- and metabolic disease and delivers candidate drugs into late-stage clinical development. In the Bioscience Cardiovascular department, we focus on identifying and validating new drug targets for treatment of patients with cardiovascular disease and heart failure, as well as evaluating pharmacological aspects, e.g. efficacy and mechanism of action, of potential new drug candidates. The in vitro team delivers key data to projects across all phases of the drug discovery and development process, and we work with different modalities such as small molecules, modified mRNA, antibodies, cell therapy, antisense oligonucleotides and peptides.

What you'll do

As an Associate Principal Scientist you will get the opportunity to join the Cardiovascular in vitro team where you will play a key role in driving science and projects forward. In this role you will work as an expert and initiate and plan for in vitro and in vivo model generation. You will independently identify and explore novel drug targets and support existing projects with scientific input and deliver key in vitro and ex vivo data. You will work with pluripotent stem cells (PSC) and primary cardiovascular cells along with molecular biology techniques and identify in vitro cell types for screening and initiate lab work to show suitability, and support in the in vitro lab when needed. Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. Responsibilities include:

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Take ownership as project lead, bioscience lead in drug projects or scientific platform development
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Independently analyze and interpret generated data
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Encourage, support, and directly contribute to communications of scientific findings through publications and presentations in world class scientific journals and meetings
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Prepare the preclinical pharmacology part of regulatory documents as appropriate

Essential for the role

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PhD or equivalent and strong scientific background and publication track record in relevant area
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Experience with cardiovascular biology and function in healthy and diseased systems
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Experience from leading project or research team
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Extensive experience in cell and molecular biology, biochemistry and relevant in vitro/ex vivo assays
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Entrepreneurial ways of working
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Good collaboration skills
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Strong oral and written communication skills

Desirable for the role

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Postdoc experience in a relevant field
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Experience within the cardiovascular area
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Background in drug discovery and development in the pharmaceutical industry
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Experience in handling and manipulating relevant PSC and primary human and animal cardiac cell types, including cardiomyocytes

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact Erik Ryberg at erik.ryberg(at)astrazeneca.com.

Welcome with your application no later than November 27, 2022

Where can I find out more?

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

There are many opportunities to develop yourself and your career at AstraZeneca and you will have support to develop to more senior roles within the company.