Senior Research Scientist – In vitro cardiac disease modelling

Job description
Senior Research Scientist – In vitro cardiac disease modelling

Are you an experienced scientist in the field of stem cells and gene editing? Would you like to contribute to the development of novel therapies?

This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in Applied Stem Cell Sciences group in Translational Genomics, Discovery Sciences, Biopharmaceuticals R&D, as a bench-based Senior Research Scientist to be a key player in developing therapeutics to change patients’ lives.

Responsibilities
The role
You will be based in Gothenburg Sweden, working alongside our stem cell scientists, disease area specialists and genome editing group. Using your strong knowledge and experience in stem cell biology, cell model development and CRISPR technology you will have the opportunity to work on in vitro aspects of therapeutic genome editing projects. This includes culture, genome-engineering and differentiation of induced pluripotent stem cells (iPSCs) and genetic and functional validation of engineered lines.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Key Responsibilities:
Culture and differentiation of human iPSC lines to cardiac and skeletal muscle
Perform molecular biology, biochemical, and cellular assays to evaluate the outcomes of gene editing experiments on genomic DNA, mRNA, protein, and functional levels.
Culture of human primary cells and various mammalian cell lines.
Effectively collaborate within a matrixed research team to facilitate the success of projects.
Maintain complete experimental records.


Qualifications
Minimum Requirements:
PhD in Developmental Biology, Cell Biology, Gene Editing or a BSc/MSc degree with significant experience
Proven experience with PSC biology and directed-differentiation to cardiac and/or skeletal muscle
Demonstrable experience with cell line engineering using CRISPR/CAS9
Design, develop, and optimize in vitro transfection/transduction experiments using a variety of perturbagens, including lentivirus/AAV-mediated infection
Hands-on experience with the following assay platforms: RT-qPCR, ddPCR, Flow Cytometry, ELISA, Western blots, and cellular functional assays
Experience with the culture of multiple mammalian cell types including primary cells
Excellent communication skills with ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team
Excellent organizational skills and documentation practices

The following skills are highly desirable:
Experience with NGS library prep, bioinformatic analysis, and cutting-edge molecular biology methods
Expertise with liquid handling automation technologies
Experience of setting up cell based pharmacological assays


Application
Deadline: 2022-03-17 , selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information:
Please contact Veronika Knudsen veronika.knudsen@randstad.se 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus!