Senior Scientist / Associate Principal Scientist

Do you have a passion for science with a background in LC-MS bioanalysis and would like to apply your knowledge in a company that turns ideas into life changing medicines? Then this role at AstraZeneca might be right for you!


We are now recruiting a Senior Scientist or Associate Principal Scientist in Bioanalysis to join the Drug Metabolism and Pharmacokinetics (DMPK) department within the Early Cardiovascular, Renal and Metabolism therapeutic area (CVRM). The role is located at AstraZeneca's vibrant R&D center in Gothenburg, Sweden.

The DMPK bioanalysis team delivers fundamental understanding of drug disposition, which includes bioanalysis of drug candidates in biological samples generated in non-clinical studies. The data generated provides insight to quantitative pharmacology as well as right tissue and right exposure aspects, including the fate of drug substances and metabolites. This role will continue to build our capability in bioanalysis with focus on oligonucleotides, peptides, PROTACs, and small molecules, among others.


Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate what science can do. DMPK interacts with many functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management. We thrive in a place where the bright and curious minds seamlessly come together in our inclusive environment. Join us to be part of developing future treatments for Cardiovascular, Renal and Metabolic diseases.


What you'll do
With a passion for science, you will support our growing portfolio in the CVRM disease area. You will develop quantitative methods for novel drug candidates and provide pharmacokinetic data to projects from target identification to life-cycle management. This lab-based role can be at Senior Scientist or Associate Principal Scientist level depending on the experience of the successful candidate.

Typical accountabilities in your daily work will include:

* Quantify drug candidates and their metabolites in various in vitro and in vivo samples to support PKPD (Pharmacokinetics and Pharmacodynamics) work in projects from early stage of drug discovery & development to life cycle management
* Identify new workflows and technologies to improve our ways of working aligned with drug project needs
* Communicate data and guidance to project representatives, act as an example to/for other scientists, and contribute to the overall team delivery.
* Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and keep project teams appraised of findings
* Write manuscripts and publish research together with external/internal collaborators


Essential for the role
The successful candidate is expected to have hands-on experience with LC-MS and sample preparation (e.g. different enrichment workflows, protein precipitation, LLE (Liquid Liquid Extraction), SPE (Solid Phase Extraction), and immunoprecipitation)
* PhD in a relevant discipline or MSc with equivalent experience.
* Experience of development and application of quantitative bioanalytical methods
* Good knowledge of liquid chromatography and mass spectrometry (LC-MS)
* Ability to work in cross-functional teams as well as independently
* Excellent oral and written communication skills in English


Desirable for the role
* Previous experience of quantification of oligonucleotide drugs such as antisense oligonucleotides (ASO) or small interfering RNAs (siRNA)
* Experience of lab automation
* Experience of high-resolution mass spectrometry
* Experience with other analytical technologies such as PCR, and immunoassays
* Basic understanding of DMPK
* Understanding of the overall drug discovery and development process.
* Publications in a relevant field


So, what's next?
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!
For more information about the position please contact hiring manager Mikko Hölttä, Mikko.Holtta@astrazeneca.com. Welcome with your application no later than August 26, 2022.



Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html