Senior Scientist, Biomarker Discovery and Development

Do you have expertise in Biomarker Discovery and Development in Cardiovascular, Metabolic and Renal Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? If this matches your ambition and skills, then you might be the one we are looking for!

We are now recruiting a Senior Scientist, Biomarker Discovery and Development to join the Biomarker team in the department of Translational Science and Experimental Medicine (TS&EM) within Early Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

Early Cardiovascular, Renal and Metabolism (CVRM) is accountable for the discovery and development (up to phase II) of new medicines within three main strategic areas - cardiovascular/heart failure, metabolism (diabetes and NASH) and chronic kidney disease. The Translational Sciences and Experimental Medicine (TS&EM) Department within Early CVRM has the remit to bridge early and late drug development by providing: i) target validation in humans; ii) biomarker strategy (target engagement & proof of mechanism biomarkers); iii) precision medicine strategies; and iv) human data-driven novel target identification.

The Biomarker team delivers high-quality biomarker assays for assessment of target engagement and proof-of-mechanism as well as for precision medicine hypothesis generation from in vitro and in vivo models up to patients.

What you'll do

As a Biomarker Scientist, you will be a key member in the Biomarker Discovery and Development team and play a key role from preclinical to clinical biomarker delivery for progressing projects and science. This role will be primarily lab based and contribute to building the biomarker strategy i.e., driving biomarker discovery for identification of target-related biomarkers and for precision medicine hypothesis generation. You will be responsible for delivering high quality and robust biomarker data package to support project progression across the CVRM project portfolio. This involves implementation of novel biomarker methods with focus on RNA / DNA and protein technologies using state of the art analytical techniques, biomarker analysis, reporting biomarker data and evaluation to the project teams.

Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca. In this role, you will have the opportunity to try novel techniques and ideas for identification of new biomarkers.

Essential for the role

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PhD or equivalent in relevant field
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Deep expertise in a range of analytical techniques for biomarker analysis (RNA/DNA nucleotides, proteins, peptides), specifically TaqMan analysis, immunoassay/ELISA platforms.
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Hands on research experience in development of novel bioanalytical methods for quantification of biomarkers within cardiovascular, renal and metabolism
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Hands on research experience in development of urinary exosomes and various blood cells for assessment of target engagement
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Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
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Excellent English communication skills, both verbal and written

Desirable for the role

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Biotech/pharma industry experience
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Experience in NGS, LC MS technology
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Experience of working with external vendors, collaborators, biobanks

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact Pia Davidsson, pia.davidsson(at)astrazeneca.com. We welcome your application, no later than September 27th.

Where can I find out more?

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D sites. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.