Senior Scientist - in vivo

At AstraZeneca Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients.



We are now recruiting a Senior Scientist in vivo to join the Drug Metabolism and Pharmacokinetics (DMPK) department within Early Respiratory & Immunology (Early R&I). This position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden, one of AstraZeneca's three strategic science
centers.



You will be part of the multiskilled In Vitro and In Vivo Science team where non-routine in vitro and in vivo studies are performed to support specific issues in our drug project. The remit of the team is also to conduct bioanalysis and metabolite investigations from various studies.


What you'll do
As a Senior Scientist in vivo, you will be responsible for delivering in vivo experiments of high quality in relevant species to support PKPD (Pharmacokinetics and Pharmacodynamics) related questions in our drug projects from target selection to LCM (life cycle management). You will work in a team to plan and design studies where PK parameters can be calculated from drug concentrations in blood and tissues and time points.


Typical accountabilities in your daily work:

* As an in vivo scientist you will be responsible for design, conduct, interpretation and reporting of in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies
* You will apply various administration and sampling techniques in different tissues and species to guide drug projects in decision making and progress
* You will recommend, initiate and lead new innovations that ensure cutting-edge DMPK science is applied to support projects
* You will initiate new collaboration within AstraZeneca as well as with external partners to drive in vivo PK science into the future

Essential for the role
* PhD or MSc degree in biology, animal science, pharmacokinetics or equivalent experience in a relevant field
* Broad experience of different administration and sampling techniques including tissue harvesting from different species
* Broad knowledge about ADME processes and relevant in vivo models of drug disposition, and track record in development, characterization and application of translatable in vivo models
* Excellent interpersonal skills that lead to successful collaborative working relationships and ability to work in cross-functional teams on a day to day basis as well as independently
* Strong customer and delivery focus with good communication skills in English, both verbal and in writings

About AstraZeneca in Gothenburg
Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. The site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've created a series of environments where innovation can happen.



About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we're proud to have an inspiring workplace culture that encourages innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.



What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until September 30, 2022.



Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg, Sweden: https://www.movetogothenburg.com/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html