Thesis work: Identification of Antisense oligonucleotides

Job description
Investigation of biotransformation of antisense oligonucleotides using liquid chromatography-high-resolution mass spectrometry and radioactivity detections.

Do you want to learn the state-of-the-art technology in analytical chemistry? Would you like to learn and build on your expertise in biotransformation of oligonucleotide therapeutics in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!

Thesis project: 30 credits
Student location: AstraZeneca, Gothenburg, Sweden
Start: January 2022

Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. Early CVRM is a global function with research units in Gaithersburg, US, Cambridge, UK and Gothenburg, Sweden. DMPK Drug Design and Biotransformation team is part of the DMPK department and based in AstraZeneca’s world-class R&D center in Gothenburg Sweden.  DMPK interacts with other functions in supporting  CVRM projects all along the value chain, from target selection all the way to market launch and Life cycle management.

Responsibilities
Oligonucleotides are a new class of drug molecules of increasing interest for a range of therapeutic indications. The analytical technologies and data processing approaches that apply in biotransformation of oligonucleotides are challenging and requiring further improvement. 

We propose an opportunity to work closely with our scientists to investigate several key steps in the analytical method development for metabolite profiling of antisense oligonucleotides in biological samples, including sample preparation, separation, and detection. Data processing methods will also be evaluated by comparing a few different softwares. High resolution mass spectrometry as well as radioactivity detection will be used.  Results of this study are expected to contribute significantly to the development of the best-in-practise bioanalytical and data processing approach for biotransformation studies in oligonucleotide platform.

Qualifications
Essential Requirements
Expertise in analytical chemistry
Good communication skills in English

Desirable Requirements
Background in Chemistry, Organic chemistry, or biochemistry.


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.

Deadline for application: 2021-11-14

For more information: Veronika Knudsen veronika.knudsen@randstad.se or Kerstin Karlsson kerstin.karlsson@randstad.se

About the company
At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of  coffee or a stroll on our “walk and talk” meeting trail. AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.