Senior Research Scientist - Genome Editing

Modis Life Science is now looking for a Senior Research Scientist for a consultancy assignment at AstraZeneca in Gothenburg. In this assignment you will work with Genome Editing. As a consultant you will be hired by Modis and work at our customers facilities in Mölndal. Send your application no later than February 27th.

The Arena:

The precise genome editing group is developing new tools and technologies to facilitate target validation, speedy disease modeling and to evaluate the potential applications and safety of therapeutic genome editing. We are part of the Translational Genomics department where we develop advanced cellular and animal models and we also provide expert support for Next Generation Sequencing and Transcriptome analysis. The candidate will be embedded in an international group working on cutting edge technologies with world leading external collaborators.

This is a temporary position, lasting for 12 months.

Tasks and responsibilities/The role:

• To design and build genome editing-based strategies and tools required to generate in vivo (mouse) and in vitro reagents to create disease models
• To develop delivery tools to improve the efficiency of genome editing
• To perform confirmation of genetic manipulation and functional validation of engineered cells and animals
• To perform target validation studies in early projects

Minimum requirements

• Molecular biology expertise on vector design and genetic manipulation of cell lines and/or mouse embryonic stem cells, primary and iPSC cells
• Functional characterization of gene modified cell lines (DNA, RNA and protein levels, cellular assays)
• In silico construct design and analysis of genetic perturbation after genome editing

Preferred experience and key factors

• Previous practical expertise with genome editing tools including Cas9/CRISPR, ZFNs and TALENs
• Hands on experience with RNA and protein detection, Next Generation Sequencing library preparation and results analysis